Recerca

El laboratori d’Immunologia està molt implicat en la recerca amb una perspectiva de col·laboració multidisciplinar i dimensió internacional. Les nostres línies d’investigació es poden englobar en:

1. Anàlisi dels mecanismes de tolerància immunològica: El seu objectiu és identificar nous biomarcadors i abordatges terapèutics pel tractament de malalties autoimmunitàries com ara diabetis tipus 1, esclerosi múltiple o tiroidopaties autoimmunitàries. Per això, el grup ha implementat diversos  models murins experimentals d’autoimmunitat en diabetis i esclerosi múltiple remitent-recurrent  i crònica-progressiva, així com  models experimentals in vitro. Aquesta investigació bàsica es realitza a les instalacions de la Fundació Institut d’ Investigació Germans Trias i Pujol (IGTP), i en col·laboració de les plataformes de l’IGTP i d’investigadors de diversos països.
   

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2.  Innovació en immunologia diagnòstica: El seu objectiu és trobar marcadors diagnòstics i de resposta a tractaments. Es treballa en la identificació de biomarcadors capaços d’identificar pacients responedors i no responedors a un tractament, mitjançant el seguiment immunològic de pacients que estan rebent tractaments immunomoduladors i immunosupresors. Així, es pot oferir a cada pacient el millor tractament disponible. Aquesta recerca es fa amb una estreta col·laboració amb diferents grups clínics de l’Hospital Germans Trias i Pujol i altres centres catalans i nacionals.

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   Immunoteràpia: Els avenços en l’estudi dels mecanismes d’inducció de tolerància immunològica han permés que els investigadors del servei d’Immunologia hagin estat pioners en el desenvolupament  de noves teràpies per al tractament de malalties autoimmunitàries. Algunes d’aquestes estratègias han estat patentades i es treballa per poder aplicar-les en pacients en un futur pròxim.  A més, s’ha desenvolupat un tractament amb cèl·lules dels propis pacients per tractar l’esclerosi múltiple que ja ha estat aprovat per la Agència Espanyola del Medicament (Eudra CT:2015-003541-26). Actualment, s’han inclòs els primers pacients en un assaig clínic multicèntric internacional coordinat pel nostre centre, i finançat majoritàriament per la Unió Europea (Programa Horitzó 2020).

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4. Clínica- epidemiològica: El seu objectiu és analitzar les dades obtingudes de la pràctica clínica i de la recerca. Gràcies a això, es poden implementar al Laboratori Clínic els millors algoritmes diagnòstics i les millors tecnologies disponibles pel diagnòstic dels nostres pacients. Aquesta recerca es fa en col.laboració amb consorcis i grups de treball nacionals i internacionals, i és d’importància cabdal per a la millora contínua del laboratori diagnòstic.

 

PUBLICACIONS

• Monitoring CD49d receptor occupancy: A method to optimize and personalize natalizumab therapy in multiple sclerosis patients. Puñet-Ortiz J, Hervás-García JV, Teniente-Serra A, Cano-Orgaz A, Mansilla MJ, Quirant-Sánchez B, Navarro-Barriuso J, Fernández-Sanmartín MA, Presas-Rodríguez S, Ramo-Tello C, Martínez-Cáceres EM. Cytometry B Clin Cytom. 2017 Apr 5. doi: 10.1002/cyto.b.21527. [Epub ahead of print]

PMID: 28378895

• Remission Phase in Paediatric Type 1 Diabetes: New Understanding and Emerging Biomarkers. Fonolleda M, Murillo M, Vázquez F, Bel J, Vives-Pi M.Horm Res Paediatr. 2017 Aug 3. doi: 10.1159/000479030. [Epub ahead of print]

PMID:28772271   Free Article

• Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis. Pujol-Autonell I, Mansilla MJ, Rodriguez-Fernandez S, Cano-Sarabia M, Navarro-Barriuso J, Ampudia RM, Rius A, Garcia-Jimeno S, Perna-Barrull D, Martinez-Caceres E, Maspoch D, Vives-Pi M. Nanomedicine (Lond). 2017 Jun;12(11):1231-1242. doi: 10.2217/nnm-2016-0410.

PMID: 28593827 Free Article

• Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis. Stojanovic I, Dimitrijevic M, Vives-Pi M, Mansilla MJ, Pujol-Autonell I, Rodríguez-Fernandez S, Palova-Jelínkova L, Funda DP, Gruden-Movsesijan A, Sofronic-Milosavljevic L, Hilkens CMU, Martinez-Caceres E, Miljkovic D. Curr Pharm Des. 2017;23(18):2623-2643. doi: 10.2174/1381612823666170214120708.

PMID: 28201972

• Clinical-scale expansion of CD34⁺ cord blood cells amplifies committed progenitors and rapid scid repopulation cells. Casamayor-Genescà A, Pla A, Oliver-Vila I, Pujals-Fonts N, Marín-Gallén S, Caminal M, Pujol-Autonell I, Carrascal J, Vives-Pi M, Garcia J, Vives J. N Biotechnol. 2017 Mar 25;35:19-29. doi: 10.1016/j.nbt.2016.10.011. Epub 2016 Oct 31.

PMID: 27810336

• Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. Lord P, Spiering R, Aguillon JC, Anderson AE, Appel S, Benitez-Ribas D, Ten Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van Kooten C, Lopez Diaz de Cerio A, Nikolic T, Oral HB, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres EM, Hilkens CMU. PeerJ. 2016 Aug 30;4:e2300. doi: 10.7717/peerj.2300. eCollection 2016.

PMID: 27635311 Free PMC Article

• Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients. Mansilla MJ, Contreras-Cardone R, Navarro-Barriuso J, Cools N, Berneman Z, Ramo-Tello C, Martínez-Cáceres EM. J Neuroinflammation. 2016 May 20;13(1):113. doi: 10.1186/s12974-016-0584-9.

PMID: 27207486 Free PMC Article

• Baseline Differences in Minor Lymphocyte Subpopulations may Predict Response to Fingolimod in Relapsing-Remitting Multiple Sclerosis Patients. Teniente-Serra A, Hervás JV, Quirant-Sánchez B, Mansilla MJ, Grau-López L, Ramo-Tello C, Martínez-Cáceres EM. CNS Neurosci Ther. 2016 Jul;22(7):584-92. doi: 10.1111/cns.12548. Epub 2016 Apr 15.

PMID: 27080413

• The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells. Badia R, Pujantell M, Riveira-Muñoz E, Puig T, Torres-Torronteras J, Martí R, Clotet B, Ampudia RM, Vives-Pi M, Esté JA, Ballana E. PLoS Pathog. 2016 Aug 19;12(8):e1005829. doi: 10.1371/journal.ppat.1005829. eCollection 2016 Aug.

PMID: 27541004 Free PMC Article

• CD26/DPPIV inhibition alters the expression of immune response-related genes in the thymi of NOD mice. Julián MT, Alonso N, Colobran R, Sánchez A, Miñarro A, Pujol-Autonell I, Carrascal J, Rodríguez-Fernández S, Ampudia RM, Vives-Pi M, Puig-Domingo M. Mol Cell Endocrinol. 2016 May 5;426:101-12. doi: 10.1016/j.mce.2016.02.014. Epub 2016 Feb 18.

PMID: 26911933   Free Article

• B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse. Carrascal J, Carrillo J, Arpa B, Egia-Mendikute L, Rosell-Mases E, Pujol-Autonell I, Planas R, Mora C, Mauricio D, Ampudia RM, Vives-Pi M, Verdaguer J. Eur J Immunol. 2016 Mar;46(3):593-608. doi: 10.1002/eji.201445376. Epub 2016 Jan 12.

PMID: 26639224 Free Article

• Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort. Ten Brinke A, Hilkens CM, Cools N, Geissler EK, Hutchinson JA, Lombardi G, Lord P, Sawitzki B, Trzonkowski P, Van Ham SM, Martinez-Caceres EM. Mediators Inflamm. 2015;2015:471719. doi: 10.1155/2015/471719. Epub 2015 Dec 24. Review.

PMID: 26819498 Free PMC Article

• Hurdles in therapy with regulatory T cells. Trzonkowski P, Bacchetta R, Battaglia M, Berglund D, Bohnenkamp HR, ten Brinke A, Bushell A, Cools N, Geissler EK, Gregori S, Marieke van Ham S, Hilkens C, Hutchinson JA, Lombardi G, Madrigal JA, Marek-Trzonkowska N, Martinez-Caceres EM, Roncarolo MG, Sanchez-Ramon S, Saudemont A, Sawitzki B. Sci Transl Med. 2015 Sep 9;7(304):304ps18. doi: 10.1126/scitranslmed.aaa7721. Review.

PMID: 26355029

• Type 1 Diabetes Prevention in NOD Mice by Targeting DPPIV/CD26 Is Associated with Changes in CD8⁺T Effector Memory Subset. Alonso N, Julián MT, Carrascal J, Colobran R, Pujol-Autonell I, Rodriguez-Fernández S, Teniente A, Fernández MA, Miñarro A, Ruiz de Villa MC, Vives-Pi M, Puig-Domingo M. PLoS One. 2015 Nov 10;10(11):e0142186. doi: 10.1371/journal.pone.0142186. eCollection 2015.

PMID: 26555789   Free PMC Article

• What potential is there for liposomal-based nanotherapy for the treatment of Type 1 diabetes? Vives-Pi M, Pujol-Autonell I. Nanomedicine (Lond). 2015 Oct;10(19):2955-2958. doi: 10.2217/nnm.15.140. Epub 2015 Sep 30. No abstract available.

PMID: 26419917   Free Article

• Innovative immunological strategies for type 1 diabetes. Vives-Pi M, Pujol-Autonell I. Endocrinol Nutr. 2015 Nov;62(9):419-21. doi: 10.1016/j.endonu.2015.07.003. Epub 2015 Sep 3. English, Spanish. No abstract available.

PMID: 26342847

• Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes. Pujol-Autonell I, Serracant-Prat A, Cano-Sarabia M, Ampudia RM, Rodriguez-Fernandez S, Sanchez A, Izquierdo C, Stratmann T, Puig-Domingo M, Maspoch D, Verdaguer J, Vives-Pi M. PLoS One. 2015 Jun 3;10(6):e0127057. doi: 10.1371/journal.pone.0127057. eCollection 2015.

PMID: 26039878 Free PMC Article

• How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review. Vives-Pi M, Rodríguez-Fernández S, Pujol-Autonell I. Apoptosis. 2015 Mar;20(3):263-72. doi: 10.1007/s10495-015-1090-8. Review.

PMID: 25604067   Free PMC Article

• Beneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitis. Mansilla MJ, Sellès-Moreno C, Fàbregas-Puig S, Amoedo J, Navarro-Barriuso J, Teniente-Serra A, Grau-López L, Ramo-Tello C, Martínez-Cáceres EM. CNS Neurosci Ther. 2015 Mar;21(3):222-30. doi: 10.1111/cns.12342. Epub 2014 Nov 18.

PMID: 25403984

• Similar biological effect of high-dose oral versus intravenous methylprednisolone in multiple sclerosis relapses. Grau-López L, Teniente-Serra A, Tintoré M, Rovira A, Ramió-Torrenta L, Brieva L, Saiz A, Cano A, Carmona O, Hervás JV, Martínez-Cáceres EM, Ramo-Tello C. Mult Scler. 2015 Apr;21(5):646-50. doi: 10.1177/1352458514546786. Epub 2014 Aug 21.

PMID: 25145693

• Maternal microchimerism: friend or foe in type 1 diabetes? Ye J, Vives-Pi M, Gillespie KM. Chimerism. 2014;5(2):21-3. Review.

PMID: 25093746 Free PMC Article

• Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells. Ye J, Vives-Pi M, Gillespie KM. PLoS One. 2014 Jan 31;9(1):e86985. doi: 10.1371/journal.pone.0086985. eCollection 2014.

PMID: 24498006 Free PMC Article

• Regulatory T cells and other lymphocyte subpopulations in patients with melanoma developing interferon-induced thyroiditis during high-dose interferon-α2b treatment. Soldevila B, Alonso N, Martínez-Arconada MJ, Granada ML, Boada A, Vallejos V, Fraile M, Fernández-Sanmartín MA, Pujol-Borrell R, Puig-Domingo M, Sanmartí A, Martínez-Cáceres EM. Clin Endocrinol (Oxf). 2013 Apr;78(4):621-8. doi: 10.1111/cen.12036.

PMID: 22957689

• Efferocytosis promotes suppressive effects on dendritic cells through prostaglandin E2 production in the context of autoimmunity. Pujol-Autonell I, Ampudia RM, Planas R, Marin-Gallen S, Carrascal J, Sanchez A, Marin A, Puig-Domingo M, Pujol-Borrell R, Verdaguer J, Vives-Pi M. PLoS One. 2013 May 15;8(5):e63296. doi: 10.1371/journal.pone.0063296. Print 2013.

PMID: 23691013 Free PMC Article

• Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice. Pujol-Autonell I, Ampudia RM, Monge P, Lucas AM, Carrascal J, Verdaguer J, Vives-Pi M. ISRN Endocrinol. 2013;2013:346987. doi: 10.1155/2013/346987. Epub 2013 Mar 11.

PMID: 23555060   Free PMC Article

• Biomarkers for diagnosis and monitoring of celiac disease. Vives-Pi M, Takasawa S, Pujol-Autonell I, Planas R, Cabre E, Ojanguren I, Montraveta M, Santos AL, Ruiz-Ortiz E. J Clin Gastroenterol. 2013 Apr;47(4):308-13. doi:10.1097/MCG.0b013e31827874e3. Review.

PMID: 23388848

• Urinary levels of regenerating protein Iα do not differentiate celiac patients and healthy subjects. Ruíz-Ortiz E, Santos AL, Pujol-Autonell I, Planas R, Montraveta M, Pintos G, Doladé M, Cabré E, Vives-Pi M. Biomarkers. 2013 Mar;18(2):178-80. doi: 10.3109/1354750X.2012.745903. Epub 2013 Jan 11.

PMID: 23312007

• Incretin hormones as immunomodulators of atherosclerosis. Alonso N, Julián MT, Puig-Domingo M, Vives-Pi M. Front Endocrinol (Lausanne). 2012 Sep 7;3:112. doi: 10.3389/fendo.2012.00112. eCollection 2012.

PMID: 22973260     Free PMC Article

• Overexpression of metallothionein I/II: a new feature of thyroid follicular cells in Graves’ disease. Ruiz-Riol M, Martínez-Arconada MJ, Alonso N, Soldevila B, Marchena D, Armengol MP, Sanmartí A, Pujol-Borrell R, Martínez-Cáceres EM. J Clin Endocrinol Metab. 2012 Feb;97(2):446-54. doi: 10.1210/jc.2011-1429. Epub 2011 Nov 16.

PMID: 22090273

• A prospective study of lymphocyte subpopulations and regulatory T cells in patients with chronic hepatitis C virus infection developing interferon-induced thyroiditis. Soldevila B, Alonso N, Martínez-Arconada MJ, Granada ML, Baía D, Vallejos V, Fraile M, Morillas RM, Planas R, Pujol-Borrell R, Martínez-Cáceres EM, Sanmartí AM. Clin Endocrinol (Oxf). 2011 Oct;75(4):535-43. doi: 10.1111/j.1365-2265.2011.04112.x.

PMID: 21592168

• Regenerating gene Iα is a biomarker for diagnosis and monitoring of celiac disease: a preliminary study. Planas R, Pujol-Autonell I, Ruiz E, Montraveta M, Cabre E, Lucas-Martin A, Pujol-Borrell R, Martinez-Caceres E, Vives-Pi M. Transl Res. 2011 Sep;158(3):140-5. doi: 10.1016/j.trsl.2011.04.004. Epub 2011 May 30.

PMID: 21867979

• Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. Arif S, Moore F, Marks K, Bouckenooghe T, Dayan CM, Planas R, Vives-Pi M, Powrie J, Tree T, Marchetti P, Huang GC, Gurzov EN, Pujol-Borrell R, Eizirik DL, Peakman M. Diabetes. 2011 Aug;60(8):2112-9. doi: 10.2337/db10-1643. Epub 2011 Jun 9.

PMID: 21659501 Free PMC Article

• Analysis of the cumulative changes in Graves’ disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors. Ruiz-Riol M, Barnils Mdel P, Colobran Oriol R, Pla AS, Borràs Serres FE, Lucas-Martin A, Martínez Cáceres EM, Pujol-Borrell R. J Autoimmun. 2011 May;36(3-4):189-200. doi: 10.1016/j.jaut.2011.01.002. Epub 2011 Feb 26.

PMID: 21354768

• Undiagnosed thyroid dysfunction, thyroid antibodies, and iodine excretion in a Mediterranean population. Lucas A, Julián MT, Cantón A, Castell C, Casamitjana R, Martínez-Cáceres EM, Granada ML. Endocrine. 2010 Dec;38(3):391-6. doi: 10.1007/s12020-010-9397-2. Epub 2010 Oct 23.

PMID: 20972723

• Serum autoimmune gastritis markers, pepsinogen I and parietal cell antibodies, in patients with type 1 diabetes mellitus: a 5-year prospective study. Alonso N, Granada ML, Soldevila B, Salinas I, Joaquin C, Reverter JL, Juncà J, Martínez Cáceres EM, Sanmartí A. J Endocrinol Invest. 2011 May;34(5):340-4. doi: 10.3275/7104. Epub 2010 Jun 4.

PMID: 20530988

• A prospective study of T- and B-lymphocyte subpopulations, CD81 expression levels on B cells and regulatory CD4(+) CD25(+) CD127(low/-) FoxP3(+) T cells in patients with chronic HCV infection during pegylated interferon-alpha2a plus ribavirin treatment. Soldevila B, Alonso N, Martínez-Arconada MJ, Morillas RM, Planas R, Sanmartí AM, Martínez-Cáceres EM. J Viral Hepat. 2011 Jun;18(6):384-92. doi: 10.1111/j.1365-2893.2010.01317.x.

PMID: 20487258

• Neonatal lupus erythematosus: a possible role for anti-Sm antibodies. Ortiz-Santamaria V, Olive A, Martinez-Cáceres E, Coll M, Codina X, Surís X. Lupus. 2010 Apr;19(5):659-61. doi: 10.1177/0961203309349385. Epub 2010 Feb 4. No abstract available.

PMID: 20133347

• Why are levels of maternal microchimerism higher in type 1 diabetes pancreas? Vanzyl B, Planas R, Ye Y, Foulis A, de Krijger RR, Vives-Pi M, Gillespie KM. Chimerism. 2010 Oct;1(2):45-50. doi: 10.4161/chim.1.2.13891.

PMID: 21327046 Free PMC Article

• TCR bias of in vivo expanded T cells in pancreatic islets and spleen at the onset in human type 1 diabetes. Codina-Busqueta E, Scholz E, Muñoz-Torres PM, Roura-Mir C, Costa M, Xufré C, Planas R, Vives-Pi M, Jaraquemada D, Martí M. J Immunol. 2011 Mar 15;186(6):3787-97. doi: 10.4049/jimmunol.1002423. Epub 2011 Feb 16.

PMID: 21325620 Free Article

• Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery. Planas R, Pujol-Borrell R, Vives-Pi M. Immunol Lett. 2010 Oct 30;133(2):55-61. doi: 10.1016/j.imlet.2010.08.001. Epub 2010 Aug 11. Review.

PMID:20708640

• Cytoprotective effect of low-dose tacrolimus on islets of Langerhans in cultures subjected to stimulation by acute rejection cytokines. Balibrea del Castillo JM, Arias-Díaz J, García Martín MC, Vives-Pi M, García Pérez JC, Cantero Cid R, Vara Ameigeiras E, Balibrea Cantero JL.Cir Esp. 2010 Jun;87(6):372-7. doi: 10.1016/j.ciresp.2010.03.009. Epub 2010 May 10. Spanish.

PMID: 20452578

• Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis. Alonso N, Martínez-Arconada MJ, Granada ML, Soldevila B, Cantón A, Mate JL, Sanmartí A, Martínez-Cáceres EM. Endocrine. 2009 Jun;35(3):420-8. doi: 10.1007/s12020-009-9166-2. Epub 2009 Mar 17.

PMID: 19291424

• Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes. Marin-Gallen S, Clemente-Casares X, Planas R, Pujol-Autonell I, Carrascal J, Carrillo J, Ampudia R, Verdaguer J, Pujol-Borrell R, Borràs FE, Vives-Pi M. Clin Exp Immunol. 2010 May;160(2):207-14. doi: 10.1111/j.1365-2249.2009.04082.x. Epub 2009 Dec 17.

PMID: 20030670   Free PMC Article

• Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes. Planas R, Carrillo J, Sanchez A, de Villa MC, Nuñez F, Verdaguer J, James RF, Pujol-Borrell R, Vives-Pi M. Clin Exp Immunol. 2010 Jan;159(1):23-44. doi: 10.1111/j.1365-2249.2009.04053.x. Epub 2009 Nov 11.

PMID: 1991225 Free PMC Article

• Characterisation of the NES2Y cell line and its use in the production of human glucose-responsive insulin producing (hGRIP) cell lines by cell-cell fusion. Adams GG, Uddin A, Vives-Pi M, Pujol-Borrell R, James RF. Islets. 2009 Sep-Oct;1(2):117-23. doi: 10.4161/isl.1.2.9432.

PMID: 21099259

• Anti-peripherin B lymphocytes are positively selected during diabetogenesis. Carrillo J, Puertas MC, Planas R, Pastor X, Alba A, Stratmann T, Pujol-Borrell R, Ampudia RM, Vives-Pi M, Verdaguer J. Mol Immunol. 2008 Jun;45(11):3152-62. doi: 10.1016/j.molimm.2008.03.003. Epub 2008 Apr 23.

PMID: 18433871

• Natural killer cells are required for accelerated type 1 diabetes driven by interferon-beta. Alba A, Planas R, Clemente X, Carrillo J, Ampudia R, Puertas MC, Pastor X, Tolosa E, Pujol-Borrell R, Verdaguer J, Vives-Pi M. Clin Exp Immunol. 2008 Mar;151(3):467-75. doi: 10.1111/j.1365-2249.2007.03580.x. Epub 2008 Jan 8.

PMID: 18190608   Free PMC Article

• Peripherin is a relevant neuroendocrine autoantigen recognized by islet-infiltrating B lymphocytes. Puertas MC, Carrillo J, Pastor X, Ampudia RM, Planas R, Alba A, Bruno R, Pujol-Borrell R, Estanyol JM, Vives-Pi M, Verdaguer J. J Immunol. 2007 May 15;178(10):6533-9.

PMID: 17475883   Free Article

• Phenotype and functional characteristics of islet-infiltrating B-cells suggest the existence of immune regulatory mechanisms in islet milieu. Puertas MC, Carrillo J, Pastor X, Ampudia RM, Alba A, Planas R, Pujol-Borrell R, Vives-Pi M, Verdaguer J.Diabetes. 2007 Apr;56(4):940-9.

PMID: 17395741   Free Article

• Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis. Alonso N, Granada ML, Salinas I, Reverter JL, Flores L, Ojanguren I, Martínez-Cáceres EM, Sanmartí A. Eur J Endocrinol. 2007 Dec;157(6):763-9.

PMID: 18057384 Free Article

• Evaluation of splenic function by dynamic gammagraphy, study of pitted erythrocytes and submembranous vacuoles in patients with slight and severe splenic trauma receiving conservative treatment or splenectomy. Pacha-González MA, Oller-Sales B, Feliu E, Millá F, Xandri M, Troya J, Roca J, Riba J, Fraile M, Martínez-Cáceres EM, Rodríguez N, Martínez MJ, Pujol-Borrell R, Fernández-Llamazares J. Med Clin (Barc). 2007 Feb 10;128(5):161-7; quiz 1 p following 200. Spanish.

PMID: 17298776

• Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation. Hidalgo J, Penkowa M, Espejo C, Martínez-Cáceres EM, Carrasco J, Quintana A, Molinero A, Florit S, Giralt M, Ortega-Aznar A. Exp Biol Med (Maywood). 2006 Oct;231(9):1450-8.

PMID: 17018866

• One-tube-PCR technique for CCL2, CCL3, CCL4 and CCL5 applied to fine needle aspiration biopsies shows different profiles in autoimmune and non-autoimmune thyroid disorders. Ferrer-Francesch X, Caro P, Alcalde L, Armengol MP, Ashhab Y, Lucas-Martín A, Martínez-Cáceres EM, Juan M, Pujol-Borrell R. J Endocrinol Invest. 2006 Apr;29(4):342-9.

PMID: 16699301

• Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFNbeta. Planas R, Alba A, Carrillo J, Puertas MC, Ampudia R, Pastor X, Okamoto H, Takasawa S, Gurr W, Pujol-Borrell R, Verdaguer J, Vives-Pi M. Diabetologia. 2006 Oct;49(10):2379-87. Epub 2006 Aug 10.

PMID: 16900387

• The role of methallothioneins in experimental autoimmune encephalomyelitis and multiple sclerosis. Espejo C, Martínez-Cáceres EM. Ann N Y Acad Sci. 2005 Jun;1051:88-96. Review.

PMID: 16126947

• Time-course expression of CNS inflammatory, neurodegenerative tissue repair markers and metallothioneins during experimental autoimmune encephalomyelitis. Espejo C, Penkowa M, Demestre M, Montalban X, Martínez-Cáceres EM. Neuroscience. 2005;132(4):1135-49.

PMID: 16078373

• Syngeneic islet transplantation into seminal vesicles of diabetic rats. Luna A, Julián JF, Alba A, Garcia-Cuyás F, Broggi MA, Ciancio G, Pujol-Borrell R, Fernández-Llamazares J, Vives-Pi M. J Invest Surg. 2005 Jan-Feb;18(1):13-8.

PMID: 15804947

• Islet-infiltrating B-cells in nonobese diabetic mice predominantly target nervous system elements. Carrillo J, Puertas MC, Alba A, Ampudia RM, Pastor X, Planas R, Riutort N, Alonso N, Pujol-Borrell R, Santamaria P, Vives-Pi M, Verdaguer J. Diabetes. 2005 Jan;54(1):69-77.

PMID: 15616012 Free Article

• IFN-beta treatment modulates the CD28/CTLA-4-mediated pathway for IL-2 production in patients with relapsing-remitting multiple sclerosis. Espejo C, Brieva L, Ruggiero G, Río J, Montalban X, Martínez-Cáceres EM. Mult Scler. 2004 Dec;10(6):630-5.

PMID: 15584487

• CD4-CD8 and CD28 expression in T cells infiltrating the vitreous fluid in patients with proliferative diabetic retinopathy: a flow cytometric analysis. Cantón A, Martinez-Cáceres EM, Hernández C, Espejo C, García-Arumí J, Simó R. Arch Ophthalmol. 2004 May;122(5):743-9.

PMID: 15136323

• Metallothionein expression in the central nervous system of multiple sclerosis patients. Penkowa M, Espejo C, Ortega-Aznar A, Hidalgo J, Montalban X, Martínez Cáceres EM. Cell Mol Life Sci. 2003 Jun;60(6):1258-66.

PMID: 12861391

• Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis. Penkowa M, Espejo C, Martínez-Cáceres EM, Montalban X, Hidalgo J. Cell Mol Life Sci. 2003 Jan;60(1):185-97.

PMID: 12613667

• IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice. Alba A, Puertas MC, Carrillo J, Planas R, Ampudia R, Pastor X, Bosch F, Pujol-Borrell R, Verdaguer J, Vives-Pi M.J Immunol. 2004 Dec 1;173(11):6667-75.

PMID: 15557158   Free Article

• Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells. Vives-Pi M, Somoza N, Fernández-Alvarez J, Vargas F, Caro P, Alba A, Gomis R, Labeta MO, Pujol-Borrell R. Clin Exp Immunol. 2003 Aug;133(2):208-18.

PMID: 12869026   Free PMC Article

• Interferon-gamma regulates oxidative stress during experimental autoimmune encephalomyelitis. Espejo C, Penkowa M, Sáez-Torres I, Hidalgo J, García A, Montalban X, Martínez-Cáceres EM. Exp Neurol. 2002 Sep;177(1):21-31.

PMID: 12429207

• Expression of chemokine receptors in the different clinical forms of multiple sclerosis. Martínez-Cáceres EM, Espejo C, Brieva L, Pericot I, Tintoré M, Sáez-Torres I, Montalban X. Mult Scler. 2002 Oct;8(5):390-5.

PMID: 12356205

• Specific proliferation towards myelin antigens in patients with multiple sclerosis during a relapse. Sáez-Torres I, Brieva L, Espejo C, Barrau MA, Montalban X, Martínez-Caceres EM. Autoimmunity. 2002 Feb;35(1):45-50.

PMID: 11908706

• Treatment with methylprednisolone in relapses of multiple sclerosis patients: immunological evidence of immediate and short-term but not long-lasting effects. Martínez-Cáceres EM, Barrau MA, Brieva L, Espejo C, Barberà N, Montalban X. Clin Exp Immunol. 2002 Jan;127(1):165-71.

PMID: 11882048 Free PMC Article

• Islet transplantation in seminal vesicles restores glycemia in diabetic rats: a preliminary study. Luna A, Julián JF, Alba A, Colobran R, Garcia-Cuyàs F, Fernández-Figueras MT, Broggi MA, Llamazares JF, Pujol-Borrell R, Vives-Pi M.Transplant Proc. 2002 Feb;34(1):196-9. No abstract available.

PMID: 11959246

• Engraftment of islets obtained by collagenase and Liberase in diabetic rats: a comparative study. Vargas F, Julián JF, Llamazares JF, Garcia-Cuyàs F, Jiménez M, Pujol-Borrell R, Vives-Pi M. Pancreas. 2001 Nov;23(4):406-13.

PMID: 11668211

• Treatment with anti-interferon-gamma monoclonal antibodies modifies experimental autoimmune encephalomyelitis in interferon-gamma receptor knockout mice. Espejo C, Penkowa M, Sáez-Torres I, Xaus J, Celada A, Montalban X, Martínez-Cáceres EM. Exp Neurol. 2001 Dec;172(2):460-8.

PMID: 11716570

• Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis. Penkowa M, Espejo C, Martínez-Cáceres EM, Poulsen CB, Montalban X, Hidalgo J. J Neuroimmunol. 2001 Oct 1;119(2):248-60.

PMID: 11585628

• Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis. Espejo C, Carrasco J, Hidalgo J, Penkowa M, Garcia A, Sáez-Torres I, Martínez-Cáceres EM. Neuroscience. 2001;105(4):1055-65.

PMID: 11530242

• Similar pro- and anti-inflammatory cytokine production in the different clinical forms of multiple sclerosis. Durán I, Martínez-Cáceres EM, Brieva L, Tintoré M, Montalban X. Mult Scler. 2001 Jun;7(3):151-6.

PMID: 11475437

• CD4(+)CD45RO(+)CD49d(high) cells are involved in the pathogenesis of relapsing-remitting multiple sclerosis. Barrau MA, Montalban X, Sáez-Torres I, Brieva L, Barberà N, Martínez-Cáceres EM. J Neuroimmunol. 2000 Nov 1;111(1-2):215-23.

PMID: 11063841

• Peptide T does not ameliorate experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Sáez-Torres I, Espejo C, Pérez JJ, Acarín N, Montalban X, Martínez-Cáceres EM. Clin Exp Immunol. 2000 Jul;121(1):151-6.

PMID: 10886253 Free PMC Article

• Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-beta? Montalban X, Durán I, Río J, Sáez-Torres I, Tintoré M, Martínez-Cáceres EM. J Neurol. 2000 Apr;247(4):259-62.

PMID: 10836616

• Immunological profile of patients with primary progressive multiple sclerosis. Expression of adhesion molecules. Durán I, Martínez-Cáceres EM, Río J, Barberà N, Marzo ME, Montalban X. Brain. 1999 Dec;122 ( Pt 12):2297-307.

PMID: 10581223

• HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules. Catálfamo M, Serradell L, Roura-Mir C, Kolkowski E, Sospedra M, Vives-Pi M, Vargas-Nieto F, Pujol-Borrell R, Jaraquemada D. Int Immunol. 1999 Feb;11(2):269-77.

PMID:10069425

• Endotoxin contamination may be responsible for the unexplained failure of human pancreatic islet transplantation. Vargas F, Vives-Pi M, Somoza N, Armengol P, Alcalde L, Martí M, Costa M, Serradell L, Dominguez O, Fernández-Llamazares J, Julian JF, Sanmartí A, Pujol-Borrell R. Transplantation. 1998 Mar 15;65(5):722-7.

PMID: 9521209

• Amelioration of flulike symptoms at the onset of interferon beta-1b therapy in multiple sclerosis by low-dose oral steroids is related to a decrease in interleukin-6 induction. Martínez-Cáceres EM, Río J, Barrau M, Durán I, Borrás C, Tintoré M, Montalban X. Ann Neurol. 1998 Oct;44(4):682-5.

PMID: 9778268

• Endotoxin activity of collagenase and human islet transplantation. Vargas F, Vives-Pi M, Somoza N, Fernández-Llamazares J, Pujol-Borrell R. Lancet. 1997 Aug 30;350(9078):641. No abstract available.

PMID: 9288056

• Proteasome subunits, low-molecular-mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin-dependent diabetes mellitus: implications for autoimmunity. Vives-Pi M, Vargas F, James RF, Trowsdale J, Costa M, Sospedra M, Somoza N, Obiols G, Tampé R, Pujol-Borrell R. Tissue Antigens. 1997 Aug;50(2):153-63.

PMID:9271825

• Advantages of using a cell separator and metrizamide gradients for human islet purification. Vargas F, Vives-Pi M, Somoza N, Alcalde L, Armengol P, Martí M, Serradell L, Costa M, Fernandez-Llamazares J, Sanmartí A, Pujol-Borrell R. Transplantation. 1996 Jun 15;61(11):1562-6.

PMID: 8669097

• Expression of transporter associated with antigen processing-1 in the endocrine cells of human pancreatic islets: effect of cytokines and evidence of hyperexpression in IDDM. Vives-Pi M, Armengol MP, Alcalde L, Costa M, Somoza N, Vargas F, Jaraquemada D, Pujol-Borrell R. Diabetes. 1996 Jun;45(6):779-88.

PMID:8635653

• Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile. Somoza N, Vargas F, Roura-Mir C, Vives-Pi M, Fernández-Figueras MT, Ariza A, Gomis R, Bragado R, Martí M, Jaraquemada D, Pujol-Borrell R. J Immunol. 1994 Aug 1;153(3):1360-77. Erratum in: J Immunol 1994 Dec 1;153(11):5347.

PMID: 7913115

• Expression of glutamic acid decarboxylase (GAD) in the alpha, beta and delta cells of normal and diabetic pancreas: implications for the pathogenesis of type I diabetes. Vives-Pi M, Somoza N, Vargas F, Armengol P, Sarri Y, Wu JY, Pujol-Borrell R. Clin Exp Immunol. 1993 Jun;92(3):391-6.

PMID: 8513574 Free PMC Article

 

 

 

 

 

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